N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-[3-[(4-氟苯基)磺酰氨基]-4-甲氧基苯基]-4-苯基苯甲酰胺被报道为 STING 抑制剂。

N-[3-[(4-fluorophenyl)sulfonylamino]-4-methoxyphenyl]-4-phenylbenzamide was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.

SN-001 targets the cyclic dinucleotide binding pocket of human STING.SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells.SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling. Western Blot Analysis Cell Line:L929 cells Concentration:10 μM Incubation Time:3 h Result:Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65.

——

——

Immunology/Inflammation

STING

STING

——

——

727699-84-5

476.52

C26H21FN2O4S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (524.64 mM)

COc(ccc(NC(c(cc1)ccc1-c1ccccc1)=O)c1)c1NS(c(cc1)ccc1F)(=O)=O

——

(-20℃)

With Ice Pack

≥ 2 years