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Ro0711401
CAS No. 714971-87-6
Ro0711401 ( Ro-0711401 | Ro 0711401 )
产品货号. M24725 CAS No. 714971-87-6
Ro0711401 是 mGlu1 受体的激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
|
| 10MG | ￥1767 | 有现货 |
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| 25MG | ￥2930 | 有现货 |
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| 50MG | ￥4241 | 有现货 |
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| 100MG | ￥5751 | 有现货 |
|
| 200MG | ￥7758 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥936 | 有现货 |
|
生物学信息
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产品名称Ro0711401
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ro0711401 是 mGlu1 受体的激动剂。
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产品描述Ro0711401 is an agonist of mGlu1 receptor.
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体外实验——
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体内实验RO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days.Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice. Animal Model:Spinocerebellar ataxia type 1 (SCA1) mice (30-week old) Dosage:10 mg/kg Administration:Subcutaneous injection; once Result:Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.
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同义词Ro-0711401 | Ro 0711401
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通路Neuroscience
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靶点GluR
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受体mGluR1
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研究领域——
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适应症——
化学信息
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CAS Number714971-87-6
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分子量360.29
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分子式C18H11F3N2O3
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纯度>98% (HPLC)
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溶解度DMSO : 100 mg/mL (277.55 mM; Need ultrasonic)
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SMILESO=C(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)NC4=NC(C(F)(F)F)=CO4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT. Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology. 2014 Oct;85:91-103. doi: 10.1016/j.neuropharm.2014.05.005. E
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