Cytochalasin H

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cytochalasin H 是肌动蛋白掺入肌丝的有效抑制剂。

Cytochalasin H is a potent inhibitor of actin incorporation into filaments.

Apoptosis AnalysisCell Line:A549 cells Concentration:0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Induced apoptosis in a dose-dependent manner in the A549 cells.Cell Cycle Analysis Cell Line:A549 cells Concentration: 0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Arrested cell cycle at the G2/M phase and sub-G1 peaks.Western Blot Analysis Cell Line:A549 cells Concentration:0, 6.25, 12.5, 25 and 50 μM Incubation Time:48 h Result:Increased the protein expression levels of Bax, P53 and cleaved caspase-3 and decreased the protein expression levels of Bcl-xL, Bcl-2 and full-length caspase-3.

Animal Model:male Balb/cnu/nu mice with A549 xenograftDosage:2.5 mg/kg Administration:intraperitoneal injection; 3 injections/week,for 80 days Result:Attenuated tumor growth in vivo.

(16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate

Others

Other Targets

ET-1|MMP2

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53760-19-3

493.63

C30H39NO5

>98% (HPLC)

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C[C@@H]([C@@H]([C@H](Cc1ccccc1)N1)[C@@]([C@H]([C@@H]2O)/C=C/C[C@H](C)C[C@](C)(/C=C3)O)([C@@H]3OC(C)=O)C1=O)C2=C

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(-20℃)

With Ice Pack

≥ 2 years