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Aurintricarboxylic acid
CAS No. 4431-00-9
Aurintricarboxylic acid ( ATA | NSC-4056 | NSC 4056 | NSC4056 )
产品货号. M24401 CAS No. 4431-00-9
金三羧酸是拓扑异构酶和其他核酸酶的强抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥294 | 有现货 |
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| 100MG | ￥410 | 有现货 |
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| 200MG | ￥597 | 有现货 |
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| 500MG | ￥972 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥170 | 有现货 |
|
生物学信息
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产品名称Aurintricarboxylic acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述金三羧酸是拓扑异构酶和其他核酸酶的强抑制剂。
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产品描述Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.
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体外实验Western Blot Analysis Cell Line:T98G, A172, GBM44 glioma cells Concentration:10 μM Incubation Time:0.5 hour, 1 hour, 2 hours Result:Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines.
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体内实验——
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同义词ATA | NSC-4056 | NSC 4056 | NSC4056
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis|MicroRNA|rP2X1|rP2X3|Topoisomerase II
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研究领域——
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适应症——
化学信息
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CAS Number4431-00-9
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分子量422.35
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分子式C22H14O9
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (295.97 mM; Need ultrasonic)
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SMILESOC(c(cc(cc1)C(c(cc2)cc(C(O)=O)c2O)=C(C=C2)C=C(C(O)=O)C2=O)c1O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Liu T T , Yang T , Gao M N , et al. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations[J]. Acta Pharmacologica Sinica, 2019.
产品手册
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