Asperulosidic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Asperulosidic Acid 具有抗肿瘤、抗氧化和抗炎活性。ASPA 通过抑制 NF-κB 和丝裂原激活蛋白激酶来抑制炎症细胞因子（TNF-α、IL-6）和介质(MAPK) 信号通路。

Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.

Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) significantly down-regulates the mRNA levels of TNF-α and IL-6 in LPS-induced RAW 264.7 cells compared with the group treated with LPS alone .Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) decreases IκB-α phosphorylation in a concentration-dependent manner, decreases Erk1/2 phosphorylation at all concentration levels, but there was no effect on p-p38 . RT-PCR Cell Line:RAW 264.7 cells Concentration:40 μg/mL, 80 μg/mL, and 160 μg/mL Incubation Time:Pre-treatment 1 hour Result:Decreased TNF-α and IL-6 mRNA expression.Western Blot Analysis Cell Line:RAW 264.7 cells Concentration:40 μg/mL, 80 μg/mL, and 160 μg/mL Incubation Time:Pre-treatment 1 hour Result:Decreased IκB-α phosphorylationand Erk1/2 phosphorylation.

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ASPA

MAPK/ERK Signaling

ERK

ERK|NF-κB

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25368-11-0

432.4

C18H24O12

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (231.28 mM)

OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@@]1([H])O[C@H]2[C@@]3([H])[C@@]([C@@H](O)C=C3COC(C)=O)([H])C(C(O)=O)=CO2

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(-20℃)

With Ice Pack

≥ 2 years