ZL0580

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZL0580 通过抑制 Tat 反式激活和转录延伸以及在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。

ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.

Cell Viability Assay Cell Line:HIV-infected human CD4+ T cells.Concentration:0-8 μM.Incubation Time:2 days.Result:Suppress HIV in primary CD4+ T cell.Single treatment (8 μM) led to almost completed loss of productive HIV infection in CD4+ T cells.RT-PCR Cell Line:PBMCs of viremic HIV-infected individuals.Concentration:8 μM.Incubation Time:2 days.Result:Suppresses HIV transcription ex vivo in PBMCs of viremic HIV-infected individuals.Cell Cytotoxicity Assay Cell Line:J-Lat cells. Concentration:0-80 μM.Incubation Time:1 and 3 days.Result:Did not cause significant cell death at concentrations below 40 μM.Treatment of J-Lat cells with ZL0580 (10 μM) also did not cause significant cell death on days 2, 7, and 14 compared with NC in both PMA-activated and unstimulated cells.

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Chromatin/Epigenetic

Epigenetic Reader Domain

BRD4|HIV

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2377151-10-3

532.53

C25H23F3N4O4S

>98% (HPLC)

DMSO:250 mg/mL (469.46 mM; Need ultrasonic)

C1C[C@H](N(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F)C(=O)NC4=CC=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years