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DDO-5936
CAS No. 2355377-13-6
DDO-5936 ( —— )
产品货号. M24068 CAS No. 2355377-13-6
DDO-5936 是一种有效且特异性的 HSP90-Cdc37 PPI 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥701 | 有现货 |
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| 10MG | ￥1226 | 有现货 |
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| 25MG | ￥2046 | 有现货 |
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| 50MG | ￥2967 | 有现货 |
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| 100MG | ￥4041 | 有现货 |
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| 200MG | ￥5337 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥775 | 有现货 |
|
生物学信息
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产品名称DDO-5936
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DDO-5936 是一种有效且特异性的 HSP90-Cdc37 PPI 抑制剂。
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产品描述DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.
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体外实验DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47.
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体内实验DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group.DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. Animal Model:Mice Dosage:0~80 mg/kg Administration:P.o.Result:Showed a moderate effect at the high dose group.
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同义词——
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点HSP
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受体HSP90
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研究领域——
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适应症——
化学信息
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CAS Number2355377-13-6
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分子量495.59
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分子式C25H29N5O4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 12.5 mg/mL (25.22 mM)
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SMILESO=C(O)CN(C1=CC=C(NC2=NC(N3CCCC3)=NC=C2)C=C1)S(=O)(C4=C(C)C=C(C)C=C4C)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer[J]. Journal of medicinal chemistry, 63(3):1281-1297.
