Dimaprit dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dimaprit diHClide 是一种选择性组胺 H2 受体激动剂。 Dimaprit diHClide 还抑制 nNOS，IC50 为 49 μM。它可以刺激胃酸分泌。

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist. Dimaprit dihydrochloride also inhibits nNOS with an IC50 of 49 μM. It can stimulate gastric acid secretion.

Dimaprit has less than 0.0001% the activity of histamine on H1-receptors.Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14?μM.

Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.).Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate.

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GPCR/G Protein

Histamine Receptor

H2 receptor|nNOS

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23256-33-9

234.19

C6H15N3S·2HCl

>98% (HPLC)

H2O:<23.42mg/ml

NC(SCCCN(C)C)=N.[H]Cl.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years