UMB298

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UMB298 是一种有效的选择性 CBP/P300 bromodomain 抑制剂。 UMB298 抑制 BRD4，IC50 为 5193nM。

UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.

UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth.UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression. Cell Viability Assay Cell Line:MOLM13 and MM cells Concentration:0.01~10 μM Incubation Time:50 days Result:Inhibited cells growth.Western Blot Analysis Cell Line:MOLM13 cells Concentration:1~10 μM Incubation Time:2 hours Result:Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.RT-PCR Cell Line:MOLM13 cells Concentration:3 μM Incubation Time:2 hours Result:Down-regulated MYC expression.

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Chromatin/Epigenetic

Epigenetic Reader Domain

BRD4

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2266569-73-5

479.01

C27H31ClN4O2

>98% (HPLC)

DMSO:20mg/ml(41.75mM; need ultrasonic)

CC1=C(C2=CC3=NC(CCC4=CC=C(OC)C(Cl)=C4)=C(NC5CCCCC5)N3C=C2)C(C)=NO1

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(-20℃)

With Ice Pack

≥ 2 years