NS-2028

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NS-2028 是一种高选择性可溶性鸟苷酸环化酶 (sGC) 抑制剂（IC50：基础酶活性和 NO 刺激酶活性分别为 30 nM 和 200 nM）。

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase (IC50: 17 nM and 20 nM). NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells (IC50: 30 nM). NS-2028 inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 decreases vascular endothelial growth factor-induced angiogenesis and permeability.

Cell Proliferation Assay Cell Line:HUVEC cells Concentration:10 μM Incubation Time:24 hours Result:Decreased cell numbers in culture.Western Blot Analysis Cell Line:HUVEC cells Concentration:10 μM Incubation Time:30 mins Result:Attenuated VEGF-enhanced p38 phosphorylation.

Animal Model:Rabbit Dosage:1 g/L Administration:Deliver orally; 1g/L; 8 days Result:Inhibits VEGF-induced angiogenesis in vivo.

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Others

Other Targets

sGC

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204326-43-2

269.05

C9H5BrN2O3

>98% (HPLC)

DMSO: 250 mg/mL (929.20 mM; Need ultrasonic)

O=C1ON=C2COC3=CC=C(Br)C=C3N21

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(-20℃)

With Ice Pack

≥ 2 years