Batabulin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Batabulin 是一种抗肿瘤化合物，它与 β-微管蛋白同种型的子集共价且选择性结合，从而破坏微管聚合。

Batabulin is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death.

Cell Cycle Analysis Cell Line:MCF7 cells Concentration:30 nM, 100 nM and 300 nM Incubation Time:24 hours Result:Showed an arrest at the G2/M cell-cycle boundary.Apoptosis Analysis Cell Line:MCF7 cells Concentration:30 nM, 100 nM and 300 nM Incubation Time:24 hours or 48 hours Result:25-30% of cells showed the reduced DNA content characteristic of apoptotic cells.

Animal Model:Male athymic nude mice (nu/nu) (6-8 week-old, 20-25 g) injected with CCRF-CEM cells Dosage:40 mg/kg Administration:Intraperitoneal injection; once per week; on days 5, 12, and 19 Result:Impaired the growth of the drug-sensitive CCRF-CEM tumors.

T138067

Apoptosis

Apoptosis

Apoptosis|Tubulin β

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195533-53-0

371.26

C13H7F6NO3S

>98% (HPLC)

DMSO:100 mg/mL (269.35 mM; Need ultrasonic)

O=S(C1=C(F)C(F)=C(F)C(F)=C1F)(NC2=CC=C(OC)C(F)=C2)=O

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(-20℃)

With Ice Pack

≥ 2 years