JTE-607 HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JTE-607 是一种细胞因子产生抑制剂。 JTE-607 在急性髓性白血病细胞中诱导细胞凋亡，同时 p21waf1/cip1 增加。

JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.

RT-PCR Cell Line:human peripheral blood mononuclear cells (PBMCs)Concentration:100 nM Incubation Time:20 hours Result:Reduced the increase in the level of mRNAs of TNF-α, IL-1b, IL-6 and IL-8.

Animal Model:Male C57BL/6 mice (5 to 6 weeks old) are sensitized by injecting Corynebacterium parvumDosage:0.3, 1, 3, 10 mg/kg Administration:Administered intravenously 10 min before the LPS challenge. Result:Showed dose dependent inhibition of the mortality at 0.3 to 10 mg/kg and significant effect at 3 and 10 mg/kg.

JTE-607 | JTE 607 | JTE-607 HCl

Proteasome/Ubiquitin

Cysteine Protease

Cystine

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188791-09-5

525.3

C22H29Cl4N3O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (418.51 mM)

O=C(N(CC)C1=CC=CC=C1)C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O.[H]Cl.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years