Coniine hydrochloride ( —— )

产品货号. M23697 CAS No. 15991-59-0

COA

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HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Coniine hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Coniine 盐酸盐是一种聚酮化合物衍生的生物碱。
产品描述

Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.
体外实验

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体内实验

Animal Model:15-20 g, Swiss-Webster male mice Dosage:0.05 mg-0.2 mg Administration:I.v.Result:Clinical signs was almost immediate after injection, beginning with piloerection, tailflicking, and rapidly progressing to intention tremors, clonic convulsions, muscular weakness, lateral recumbency, and death; shows acute toxicity with an LD50 value of 7.7 mg/kg.
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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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1.Hannu H , Heiko R . The killer of Socrates: Coniine and Related Alkaloids in the Plant Kingdom[J]. Molecules, 2017, 22(11):1962.

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