PH-002

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PH-002 是神经元细胞中载脂蛋白 (apo) E4 分子内结构域相互作用的抑制剂。它还可以挽救线粒体运动和神经突生长的损伤。

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET.

PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons).

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Others

Other Targets

Apo E4 in FRET

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1311174-68-1

491.58

C27H33N5O4

>98% (HPLC)

DMSO:75 mg/mL (152.57 mM)

CC(C)(C)OC(N1CCN(Cc(cc2)ccc2NC(CC(c2c3cccc2)=NN(C)C3=O)=O)CC1)=O

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(-20℃)

With Ice Pack

≥ 2 years