Glycol chitosan

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

乙二醇壳聚糖是具有亲水性乙二醇支链的壳聚糖衍生物。

Glycol chitosan is a chitosan derivative with hydrophilic ethylene glycol branches. Glycol chitosan inhibits E. coli, S. aureus, and S. enteritidis growths (MICs: 4 μg/mL, 32 μg/mL, and <0.5 μg/mL). It enhances membrane permeability and leakage in Glycine max Harosoy 63W cells.

Glycol chitosan derivatives have been successfully applied to deliver antimicrobial agents and anticancer drugs such as chemodrugs, genes, and photosensitizers (PSs), either by physical encapsulation or chemical conjugation. Glycol chitosan can be directly linked with hydrophobic drugs to generate amphiphilic compounds that can also form nanoparticles (NPs) for cell imaging and drug delivery. The use of Glycol chitosan derivatives for cell imaging and drug delivery has several advantages, including superb tumor-homing ability in the case of Glycol chitosan NPs based on enhanced permeability and retention (EPR) effect, low cytotoxicity, ease of chemical modification, great biocompatibility, and biodegradability.The hydrophobic modification of Glycol chitosan is already confirmed, such as Glycol chitosan bearing a 5β-cholanic acid moiety and deoxycholic acid-Glycol chitosan, could self-assemble into nanoparticles, acting as a promising vehicle for hydrophobic drugs and genes.

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GPCR/G Protein

Antibacterial

E. coli|S. aureus|S. enteritidis

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123938-86-3

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>98% (HPLC)

DMSO:11.67 mg/mL (Need ultrasonic);H2O:7.5 mg/mL (Need ultrasonic)

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(-20℃)

With Ice Pack

≥ 2 years