CAY10650

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CAY10650 是胞质磷脂酶 A2α 的有效抑制剂（cPLA2α，IC50：12 nM）。

CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).

CAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells.CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils. Western Blot Analysis Cell Line: Neutrophils Concentration:12 nM Incubation Time:30 minutes Result:Inhibited cPLA2-α and inhibited the expression of the p-cPLA2-α.Western Blot Analysis Cell Line:Neutrophils Concentration:12 nM Incubation Time:2 hours Result:Inhibited the PGE2 secretion and inhibited PGE2 realease.

CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo.. Animal Model:Chinese hamsters with infected with parasite-laden contact lensesDosage:50 μg/5 μL Administration:Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection Result:Reduced the severity of the keratitis and hasten the onset of resolution.

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Metabolic Enzyme/Protease

Phospholipase

cPLA2α

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1233706-88-1

471.5

C28H25NO6

>98% (HPLC)

DMSO:40 mg/mL (84.84 mM)

O=C(C1=CC2=C(N(CC(COC3=CC=C(OC4=CC=CC=C4)C=C3)=O)C=C2C(C(C)C)=O)C=C1)O

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(-20℃)

With Ice Pack

≥ 2 years