Sodium aurothiomalate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

金硫苹果酸钠是一种金化合物，具有免疫抑制、抗风湿作用。

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium exhibits potent anti-tumor activity.

Western Blot Analysis Cell Line:Bovine arterial endothelial cells (BAEC)Concentration:25 uM Incubation Time:6 hours Result:Suppressed TNFa-induced NF-kB-dependent gene expression in a dose-dependent manner.

Animal Model:4-6-week-old female nude mice with A427 or H460 cells Dosage:2, 6, 20 or 60 mg/kg Administration:Intramuscular injections; daily; 40 days Result:Exhibited statistically significant inhibition of tumor growth at all concentrations tested in A427 cell tumors because A427 cells are highly responsive.

gold sodium thiomalate | Aurothiomalate sodium | Miochrysin | Myochrysine | Myocrisin | Myocrisine

Angiogenesis

PKC

PKC-ι|TrxR

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12244-57-4

390.07

C4H3AuNa2O4S

>98% (HPLC)

DMSO:Soluble

OC(CC(S)C(O)=O)=O.[x].[Na].[Au]

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(-20℃)

With Ice Pack

≥ 2 years