CID44216842

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CID44216842 是一种有效的 Cdc42 选择性鸟嘌呤核苷酸结合先导抑制剂。

CID44216842 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor.?The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively.?The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively.?Use as a molecular probe.

CID44216842 inhibits GTP binding to both Cdc42 and its mutant in a dose-dependent manner. The inhibition is specific toward Cdc42 with no effects on other GTPases including Rac and Rho in the same family.

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KUC103479N-02

Angiogenesis

CDK

Cdc42

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1222513-26-9

486.38

C22H20BrN3O3S

>98% (HPLC)

DMSO:250 mg/mL?(514.00 mM;?Need ultrasonic)

O=S(C1=CC=C(N2N=C(C3=CC=CC(OC)=C3)CC2C4=CC=C(Br)C=C4)C=C1)(N)=O

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(-20℃)

With Ice Pack

≥ 2 years