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Sulfuretin
CAS No. 120-05-8
Sulfuretin ( —— )
产品货号. M23371 CAS No. 120-05-8
Sulfuretin 是一种有效的抗氧化剂，对人肝源性 HepG2 细胞中 t-BHP 诱导的氧化损伤具有保护作用，这归因于其清除 ROS 并通过 Nrf2/ARE 上调 HO-1 活性的能力， JNK/ERK 信号通路。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1511 | 有现货 |
|
| 10MG | ￥2518 | 有现货 |
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| 25MG | ￥4046 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Sulfuretin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Sulfuretin 是一种有效的抗氧化剂，对人肝源性 HepG2 细胞中 t-BHP 诱导的氧化损伤具有保护作用，这归因于其清除 ROS 并通过 Nrf2/ARE 上调 HO-1 活性的能力， JNK/ERK 信号通路。
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产品描述Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways.
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体外实验Sulfuretin is one of the main flavonoids produced by Rhus verniciflua. Sulfuretin efficiently inhibits the infiltration of inflammatory cells and attenuates allergic airway inflammation.
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体内实验Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation. Animal Model:Pathogen-free male BALB/c mice (7-8 weeks old)Dosage:40 μg/kg Administration:A single intraperitoneal injection was administered 2 h after the last OVA challengeResult:Suppressed OVA-induced chemotaxis and airway inflammation.
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同义词——
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通路Autophagy
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靶点Autophagy
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受体(HO)-1
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研究领域——
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适应症——
化学信息
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CAS Number120-05-8
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分子量270.24
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分子式C15H10O5
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESC1=CC(=C(C=C1/C=C\2/C(=O)C3=C(O2)C=C(C=C3)O)O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.Int J Mol Sci. 2014 May 19;15(5):8863-77.
