EN4 MYC inhibitor

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EN4 MYC 抑制剂是一种共价配体，靶向 MYC 的半胱氨酸 171 (C171)。

EN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.

Cell Proliferation Assay Cell Line:231MFP breast cancer cells Concentration:1 μM, 10 μM, 50 μM Incubation Time:72 hours Result:Significantly impaired 231MFP breast cancer cell proliferation in a dose-dependent manner.Western Blot Analysis Cell Line:231MFP breast cancer cells Concentration:50 μM Incubation Time:60 hours Result:The protein levels of CDK2 and CDC25A were significantly lowered.

Animal Model:SCID mice injected with 231MFP breast cancer cells.Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 3 weeks Result:Significantly attenuated tumor growth in vivo.

EN4

Cell Cycle/DNA Damage

c-Myc

MYC

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1197824-15-9

416.47

C25H24N2O4

>98% (HPLC)

DMSO:250 mg/mL (600.28 mM; Need ultrasonic)

CCOC1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)CNC(=O)C=C

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(-20℃)

With Ice Pack

≥ 2 years