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IAXO-102
CAS No. 1115270-63-7
IAXO-102 ( —— )
产品货号. M23313 CAS No. 1115270-63-7
IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1169 | 有现货 |
|
| 5MG | ￥2071 | 有现货 |
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| 10MG | ￥3316 | 有现货 |
|
| 25MG | ￥5329 | 有现货 |
|
| 50MG | ￥7431 | 有现货 |
|
| 100MG | ￥9630 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称IAXO-102
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导。
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产品描述IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.
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体外实验Western Blot Analysis Cell Line:Human umbilical vein endothelial (HUVEC) cells Concentration:1-10 μM Incubation Time:Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour Result:Significantly inhibited LPS-stimulated MAPK/p65nF-ΚB phosphorylation.
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体内实验Animal Model:Six-monthold ApoE?/?/C57Bl6 Dosage:3 mg/kg/day Administration:S.C. for 28 days Result:Significantly retarded Angiotensin II-induced increase in aortic diameter.
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同义词——
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通路Immunology/Inflammation
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靶点TLR
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受体TLR4
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研究领域——
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适应症——
化学信息
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CAS Number1115270-63-7
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分子量585.94
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分子式C35H71NO5
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纯度>98% (HPLC)
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溶解度Ethanol:45 mg/mL (76.8 mM; Need ultrasonic);DMSO:< 1 mg/mL (insoluble or slightly soluble)
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SMILESCCCCCCCCCCCCCCO[C@@H]([C@@H]([C@@H](CN)O[C@@H]1OC)O)[C@H]1OCCCCCCCCCCCCCC
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.
产品手册
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