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XEN723
CAS No. 1072803-08-7
XEN723 ( —— )
产品货号. M23280 CAS No. 1072803-08-7
XEN723 是一种有效的噻唑基咪唑啉酮硬脂酰辅酶 A 去饱和酶 (SCD1) 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1121 | 有现货 |
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| 10MG | ￥1796 | 有现货 |
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| 25MG | ￥2939 | 有现货 |
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| 50MG | ￥4139 | 有现货 |
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| 100MG | ￥5301 | 有现货 |
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| 200MG | ￥7137 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1074 | 有现货 |
|
生物学信息
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产品名称XEN723
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述XEN723 是一种有效的噻唑基咪唑啉酮硬脂酰辅酶 A 去饱和酶 (SCD1) 抑制剂。
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产品描述XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
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体外实验XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit.
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体内实验——
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Dehydrogenase
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受体SCD1
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研究领域——
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适应症——
化学信息
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CAS Number1072803-08-7
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分子量425.48
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分子式C21H20FN5O2S
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (235.03 mM; Need ultrasonic)
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SMILESCc1c(C(NCc2cnccc2)=O)sc(N(CCN2Cc(cc3)ccc3F)C2=O)n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.
