DMT1 blocker 2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DMT1 阻断剂 2（化合物 12f）是二价金属转运蛋白 1 (DMT1) 的直接抑制剂，过氧化氢的 IC50 值为 0.83。

DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.

——

Animal Model:Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage:50 mg/kg Administration:Oral gavage followed 1 h later by an iron challenge Result:Attenuated the post-challenge serum iron increase.

——

Others

Other Targets

DMT1

——

——

1062648-63-8

263.29

C16H13N3O

>98% (HPLC)

DMSO:48 mg/mL?(182.3 mM;?Need ultrasonic)

OC1=C2C3=CC=CC=C3CCC2=NN1C4=NC=CC=C4

——

(-20℃)

With Ice Pack

≥ 2 years