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Smurf1-IN-A01
CAS No. 1007647-73-5
Smurf1-IN-A01 ( A01 )
产品货号. M23212 CAS No. 1007647-73-5
Smurf1-IN-A01 是一种泛素连接酶 Smad 泛素化调节因子 1 抑制剂 (kd: 3.664 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥395 | 有现货 |
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| 5MG | ￥649 | 有现货 |
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| 10MG | ￥1093 | 有现货 |
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| 25MG | ￥2167 | 有现货 |
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| 50MG | ￥3581 | 有现货 |
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| 100MG | ￥4941 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥801 | 有现货 |
|
生物学信息
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产品名称Smurf1-IN-A01
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Smurf1-IN-A01 是一种泛素连接酶 Smad 泛素化调节因子 1 抑制剂 (kd: 3.664 nM)。
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产品描述Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.
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体外实验——
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体内实验Animal Model:retinal degeneration model mice Dosage:10 μM ,2μL Administration:Injected into vitreous cavity by micro-syringe Result:Reduced drusen-like spots.Resulted outer nuclear layers wider and straighter.Caused inner segment and outer segment hinge of photoreceptor cells disappeared.Down-regulated NLRP3 and inhibited IL-1β.
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同义词A01
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通路Others
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靶点Other Targets
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受体Smurf1
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研究领域——
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适应症——
化学信息
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CAS Number1007647-73-5
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分子量512.93
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分子式C22H20ClF3N4O3S
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纯度>98% (HPLC)
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溶解度DMSO:62.5 mg/mL (121.85 mM; Need ultrasonic)
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SMILESCC1=CC=NN1C2=CC=C(C=C2)C(=O)N3CCN(CC3)S(=O)(=O)C4=CC(=C(C=C4)Cl)C(F)(F)F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci Rep. 2014 May 14;4:4965.
产品手册
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