TMN355

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TMN355 是一种有效的亲环蛋白 A 化学抑制剂，可减少泡沫细胞形成和细胞因子分泌，用于治疗动脉粥样硬化。使用 siRNA 或化学抑制剂沉默 THP-1 细胞和人单核细胞中的亲环蛋白 A，即使在暴露于氧化 LDL 后，TMN355 也会导致脂质摄取减少 65-75%。

TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p

TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation.Western Blot Analysis Cell Line:THP cell lines Concentration:0.5, 1, 2.5, 5 and 10 μM Incubation Time:3, 6 and 9 hours Result:Resulted in 75.9% reduction of cyclophilin A protein expression.

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Others

Other Targets

cyclophilin A

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1186372-20-2

380.8

C21H14ClFN2O2

>98% (HPLC)

DMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)

O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl

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(-20℃)

With Ice Pack

≥ 2 years