VUT-MK142

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VUT-MK142是一种新的心肌生成小分子，可促进心脏前中胚层分化为心肌细胞，可能有助于干细胞分化为心肌细胞以进行心脏修复。VUT-MK142被认为是最有前途的心肌生成活性候选者。

VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.VUT-MK142 was identified as the most promising candidate with respect to cardiomyogenic activity.?Treatment using this novel agent induced the strongest up-regulation of expression of the cardiac marker ANF in both P19 embryonic carcinoma cells and C2C12 skeletal myoblasts.?The activity of VUT-MK142 on this marker superseded CgC;?moreover, the novel compound significantly up-regulated the expression of other cardiac markers, and promoted the development of beating cardiomyocytes from cardiovascular progenitor cells.

VUT-MK142 possesses promising cardiomyogenic effects on various cell types. VUT-MK142 shows a remarkable effect on both P19 and C2C12 cells. Compared to CgC, VUT-MK142-treatment leads to a markedly stronger up-regulation of the expression of ANF.VUT-MK142 (1 μM, 7 day treatment) significantly (p < 0.05) increases the luciferase signal by 3.1 ± 0.3 luciferase (n = 5)-fold in P19 cells.

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Others

Other Targets

Others

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1313491-22-3

298.4

C17H22N4O

>98% (HPLC)

DMSO:25 mg/mL (83.79 mM; Need ultrasonic)

COC1=CC=C(NC2=CC(NC3CCCCC3)=NC=N2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years