Demethylwedelolactone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Demethylwedelolactone 是从 Eclipta alba 中分离出来的天然产物，具有胰蛋白酶抑制作用，IC50 为 3.0 μM。它对乳腺癌细胞发挥抗侵袭生长作用。去甲基韦德洛内酯（DWEL）抑制MDA-MB-231细胞的贴壁依赖性生长，并抑制细胞运动和细胞侵袭。

Demethylwedelolactone is a natural product isolated from Eclipta alba,?has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells.demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells.

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Proteasome/Ubiquitin

Serine Protease

trypsin

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6468-55-9

300.22

C15H8O7

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (333.09 mM)

O=C1C2=C(OC3=CC(O)=C(O)C=C32)C4=C(O)C=C(O)C=C4O1

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(-20℃)

With Ice Pack

≥ 2 years