Bisabolangelone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

红没药天使酮具有抗肿瘤、抗炎、抗菌和抗氧化活性，它通过阻断 MAPK 和 NF-κB 信号传导来抑制树突状细胞功能。红没药天使酮 (BISA) 是从当归的根中分离出来的，具有多种药理活性，例如抗肿瘤、抗微生物、抗氧化和抗炎活性。

Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities.?BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs.?In addition, BISA affected endocytosis of DCs.?Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65.??BISA inhibited DC functions by blocking MAPK and NF-κB signaling.

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MAPK/ERK Signaling

p38 MAPK

MAPK

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30557-81-4

248.32

C15H20O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (402.71 mM)

O=C1C=C(C)C[C@@]2([H])[C@]1([H])[C@@](C)(O)/C(O2)=C/C=C(C)\C

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(-20℃)

With Ice Pack

≥ 2 years