Drotaverine hydrochloride ( —— )

产品货号. M22762 CAS No. 985-12-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Drotaverine hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Drotaverine (hydrochloride) 是一种磷酸二酯酶 4 (PDE4) 的抑制剂，也是一种 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。
产品描述

Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth.?Drotaverine hydrochloride?is structurally related to papaverine?drotaverine not only relaxed the precontracted tracheal preparations but also decreased mediator-induced contraction.?These effects of drotaverine were concentration dependent, with a significantly higher potency on the KCl-induced response, than on either the histamine or methacholine induced one.?A similar result was noted for nifedipine.?The PDE inhibitor, theophylline, also relaxed the precontracted preparations but was ineffective on the mediator-induced contraction in a physiologically relevant concentration range.
体外实验

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体内实验

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同义词

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通路

Angiogenesis
靶点

PDE
受体

PDE4
研究领域

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适应症

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1. Patai, Zoltán, Guttman, András, Mikus E . Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine[J]. Pharmacology, 2018:163.

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