MitoBloCK-10

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MitoBloCK-10 抑制 Tim44 与前体和 Hsp70 的结合。MitoBloCK-10 是第一个减弱蛋白质相关运动 (PAM) 复合物活性的小分子调节剂。

MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.

Cell Viability Assay Cell Line:A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.Concentration:100 μM.Incubation Time:30 min.Result:WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil.Cell Viability Assay Cell Line:HeLa cells.Concentration:0-100 μM.Incubation Time:24 h.Result:Inhibited HeLa cells vibility, with an IC50 of 17.2 μM.

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3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m

Others

Other Targets

Others

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394694-98-5

293.28

C12H8FN3O3S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (426.23 mM)

[O-][N+](=O)c1ccc(\C=N\NC(=O)c2cccc(F)c2)s1

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(-20℃)

With Ice Pack

≥ 2 years