FEMA 4774

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FEMA 4774 是 T1R2/T1R3 的正变构调节剂。 FEMA4774在感官评价测试中显示出明显的蔗糖甜度增强作用。

FEMA 4774 is a positive allosteric modulator of T1R2/T1R3.?FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests.

FEMA 4774 (0-50 μM) induces a dose-dependent decrease in the EC50 value of sucrose and significantly enhances the affinity of sucrose for its binding site with an α (effect of modulator on agonist affinity) value of 30 in the human sweet receptor cells.

FEMA 4774 (S9632) (oral gavage, 500-2000 mg/kg) does not cause a dose-dependent increase in polychromatic erythrocytes and induces micronuclei formation at dose levels up to 2000 mg/kg in Swiss albino (CD-1) mice.The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats.

S9632

Others

Other Targets

T1R2/T1R3

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1359963-68-0

359.45

C19H25N3O4

>98% (HPLC)

In Vitro:?DMSO : ≥ 41.67 mg/mL (115.94 )

CC(C)NC(=O)C(C)(C)COc1cccc2nc(C)c(C(O)=O)c(N)c12

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(-20℃)

With Ice Pack

≥ 2 years