4-Hydroxycoumarin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

4-羟基香豆素，一种香豆素衍生物。4-羟基香豆素是 4-羟基香豆素 (4HC) 型抗凝剂（例如华法林）的直接前体。 4-羟基香豆素衍生物用作抗凝血剂、抗菌剂、抗真菌剂、抗病毒剂、抗肿瘤剂、抗原虫剂、杀虫剂、抗分枝杆菌剂、抗突变剂、抗氧化剂、抗炎剂、HIV蛋白酶抑制剂和酪氨酸激酶抑制剂。

4-Hydroxycoumarin, a coumarin derivative.4-Hydroxycoumarin serves as an immediate precursor of 4-hydroxycoumarin (4HC) type anticoagulants (for example, warfarin).?4-Hydroxycoumarin derivatives ?are employed as the anticoagulant, antibacterial, antifungal, antiviral, antitumor, antiprotozoal, insecticidal, antimycobacterial, antimutagenic, antioxidant, anti-inflammatory agents, HIV protease inhibitors and tyrosine kinase inhibitorsThe antioxidant activity of 4-Hydroxycoumarin synthetic derivatives and 4-methylumbelliferone were determined taking 4-Hydroxycoumarin as the reference compound. METHODS AND RESULTS:Six 3-aryl-4-Hydroxycoumarin derivatives were synthesized from 4-Hydroxycoumarin as precursor in order to evaluate changes in their antioxidant properties due to C3-aryl substituent nature. Free radical scavenging capacities of these compounds against two different species DPPH(·) and ABTS(·+) and the protecting ability towards the β-carotene-linoleic acid co-oxidation enzymatically induced by lipoxygenase were measured. In addition, the relationship between the activities of these molecules against DPPH radical and the bond dissociation energy of O-H (BDE) calculated using methods of computational chemistry was evaluated.

Cell Viability Assay Cell Line:B16-F10, B82 Concentration:0, 50, 160, 500 μM Incubation Time:24 h Result:Had no appreciable effect on cell viability.Western Blot Analysis Cell Line:B16-F10 Concentration:0, 50, 160, 500 μM Incubation Time:24 h Result:Reduced the adhesion to ECM proteins and the tyrosine phosphorylation of several proteins in a concentration-dependent manner.

Animal Model:Mouse melanoma modelDosage:10, 20 or 40 mg/kg Administration:i.g.Result: Reduced >85% of the number of pulmonary tumors.Diminished the tumor size from day 22 and increased survival time at 10 mg/kg/day.Animal Model:Rat colitis model Dosage:5, 10, 25, 50 mg/kg Administration:p.o.Result:Reduced damage score and extension of the lesion at doses of 10 and 25 mg/kg.Counteracted GSH content and reduced AP activity at a dose of 5 mg/kg.Showed a good recovery of the intestinal cytoarchitecture at doses of 5 and 25 mg/kg.

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Endocrinology/Hormones

AChR

AChR

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1076-38-6

162.14

C9H6O3

>98% (HPLC)

DMSO:247 mg/mL (1523.37 mM; Need ultrasonic)

Oc1cc(=O)oc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years