CHLOROQUINE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chloroquine 是一种自噬和 Toll 样受体 (TLR) 抑制剂。氯喹是一种抗疟和抗炎药，广泛用于治疗疟疾和类风湿性关节炎。

Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro with EC50 of 1.13 μM.Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased.?Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro.Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells.

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Microbiology/Virology

HIV

HIV-1|autophagy|TLR|SARS-COV-2

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54-05-7

319.87

C18H26ClN3

>98% (HPLC)

DMSO:100 mg/mL (312.63 mM); Ethanol:100 mg/mL (312.63 mM; Need ultrasonic)

CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

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(-20℃)

With Ice Pack

≥ 2 years