MLS0315771

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MLS0315771 是一种有效且具有生物活性的竞争性磷酸甘露糖异构酶 (MPI) 抑制剂（IC50：~1 μM，Ki：1.4 μM）。MLS0315771 在 2 μM 以上对斑马鱼胚胎有毒。 MLS0315771 在较高浓度下的毒性是一种脱靶效应。

MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).MLS0315771 is toxic to the zebrafish embryos above 2 μM. MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 enhances mannose flux toward glycosylation. It ~50% of embryos appeared sick within 20 min at 8-10 μM, and most of them die by 30-60 min.

MLS0315771 increases mannose flux toward glycosylation.MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 is toxic to the zebrafish embryos above 2 μM. At 8-10 μM, ~50% embryos appeare sick within 20 min, and most of them die by 30-60 min.

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Others

Other Targets

MPI

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727664-91-7

273.33

C15H12FNOS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (365.86 mM)

Cc1ccc(C)c(c1)-n1sc2cc(F)ccc2c1=O

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(-20℃)

With Ice Pack

≥ 2 years