AZ-32

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZ32 是一种具有口服生物利用度和血脑屏障穿透性的 ATM 抑制剂（ATM 酶和细胞内的 IC50 分别为 <6.2 nM 和 0.31 μM）。

AZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell)

AZ32 is a next-generation blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro.

AZ32, with enhanced BBB penetration, is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours.

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Cell Cycle/DNA Damage

ATM/ATR

ATM

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2288709-96-4

328.37

C20H16N4O

>98% (HPLC)

DMSO:150 mg/mL?(456.80 mM)

CNC(=O)c1ccc(cc1)c2cnc3cnc(cn23)c4ccccc4

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(-20℃)

With Ice Pack

≥ 2 years