LDH-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LDH-IN-1 是一种新型吡唑类人乳酸脱氢酶 (LDH) 抑制剂，对 LDHA 和 LDHB 的 IC50 值分别为 32 和 27 nM。 LDH-IN-1 抑制 MiaPaCa2 胰腺癌和 A673 肉瘤细胞的生长，IC50 分别为 2.23 和 1.21 μM。

LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.?LDH-IN-1 inhibits the growth of MiaPaCa2 pancreatic cancer and A673 sarcoma cells with IC50s of 2.23 and 1.21 μM). Dose?response treatment of MiaPaCa-2 cells with LDH-IN-1 shows effects on cellular proliferation at concentrations as low as 250 nM and with nearly complete arrest of cell growth at 20 μM[1].LDH-IN-1 exhibits low nM inhibition of both LDHA and LDHB (IC50=32, 27 nM, respectively), submicromolar inhibition of lactate production, and inhibition of lactate in MiaPaCa2 pancreatic cancer and A673 sarcoma cells (IC50=0.517, 0.854μM, respectively).LDH-IN-1 shows clearance values that far exceed hepatic blood flow ?in mouse species (90 mL/min/kg), with in vivo clearances of 227 mL/min/kg.

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Metabolic Enzyme/Protease

Dehydrogenase

LDHA|LDHB

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1964515-43-2

570.68

C30H26N4O4S2

>98% (HPLC)

DMSO:50 mg/mL (87.61 mM; Need ultrasonic)

O=S(C1=CC=C(CC2=C(N(C3=NC(C(O)=O)=CS3)N=C2C4=CC=CC(C5=CC=CC=C5)=C4)CC6CC6)C=C1)(N)=O

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(-20℃)

With Ice Pack

≥ 2 years