Anthracene-9-carboxylic acid

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Anthracene-9-carbacid 是一种氯离子转运抑制剂，对 PKA 激活的心脏 IcI 具有中度至强度的抑制作用。

Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.

Anthracene-9-carboxylic acid causes a voltage-dependent block of outward currents in HEK 293T cells and inhibits a larger fraction of the current as depolarization increased.Anthracene-9-carboxylic acid induces a strong potentiation of tail currents measured at -100 mV after depolarizing voltages, as well as a prolongation of the deactivation kinetics in HEK 293T.Anthracene-9-carboxylic acid (500 μM, rabbit pulmonary artery smooth muscle cells) produces a small inhibition of the maximum outward Cl- current at +70 mV (21±10%) but augmented the amplitude of the instantaneous inward relaxation at -80 mV by 321±34%.

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Others

Other Targets

Cl-transport

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723-62-6

222.24

C15H10O2

>98% (HPLC)

DMSO:22.22 mg/mL (100 mM)

OC(=O)c2c1ccccc1cc3ccccc23

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(-20℃)

With Ice Pack

≥ 2 years