Metoprine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Metoprine 是组胺 N-甲基转移酶 (HMT) 的有效抑制剂，具有潜在的抗肿瘤活性。在哺乳动物中，组胺 N-甲基转移酶 (HMT) 是负责降解大脑中组胺的唯一酶。

Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain.?Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT.?Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose.

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Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner.Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption. Animal Model:Male Sprague-dawley rats (200-280g)Dosage:2, 5, 10 mg/kg Administration:IP Result:Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg.

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GPCR/G Protein

Histamine Receptor

histamine N-methyltransferase| antifolate

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7761-45-7

269.13

C11H10Cl2N4

>98% (HPLC)

In Vitro:?DMSO : 20.83 mg/mL (77.40 mM)

Cc1nc(N)nc(N)c1-c1ccc(Cl)c(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years