Panitumumab ( —— )

产品货号. M22158 CAS No. 339177-26-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Panitumumab
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Panitumumab (ABX-EGF) 是一种全人源 IgG2 抗 EGFR 单克隆抗体，具有抗肿瘤活性。Panitumumab 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab 可用于癌症研究，例如结肠癌。
产品描述

Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).
体外实验

Western Blot Analysis Cell Line:EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells Concentration:2, 20, 200, 2000 nM Incubation Time:3 h Result:Inhibited ligand-induced autophosphorylation of EGFR.
体内实验

Animal Model:NCI-H1975 and NCI-H1650 xenografts Dosage:25, 100, or 500 μg/mouse Administration:Intraperitoneal injection (i.p.), twice a week Result:Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.
同义词

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通路

Angiogenesis
靶点

EGFR
受体

EGFR
研究领域

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适应症

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