TBOPP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TBOPP 是一种选择性 DOCK1 抑制剂 (IC50 : 8.4 μM)，对更广泛的肿瘤类型具有抗肿瘤活性。

TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1.?TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.

Cell Viability Assay Cell Line:3LL cells Concentration:12.5 μM Incubation Time:3 days Result:Inhibited cell viability.

Animal Model:C57BL/6 mice (6- to 8-week-old) with ex-3LL cells Dosage:0.67 mg per mouse Administration:Administrated on days 0, 1, 3, and 5; for 2 weeks Result:The lung metastasis was significantly suppressed.

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Others

Other Targets

DOCK1|DOCK1 DHR-2 domain

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1996629-79-8

490.49

C24H21F3N2O4S

>98% (HPLC)

DMSO:120 mg/mL (244.65 mM; Need ultrasonic)

FC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1

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(-20℃)

With Ice Pack

≥ 2 years