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Tripolin A
CAS No. 1148118-92-6
Tripolin A ( —— )
产品货号. M22111 CAS No. 1148118-92-6
Tripolin A 是 Aurora A 激酶的特异性非 ATP 竞争性抑制剂（Aurora A 和 Aurora B 的 IC50 值分别为 1.5 μM 和 7 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | ￥7345 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tripolin A
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tripolin A 是 Aurora A 激酶的特异性非 ATP 竞争性抑制剂（Aurora A 和 Aurora B 的 IC50 值分别为 1.5 μM 和 7 μM）。
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产品描述Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Tripolin A, a non-ATP competitive inhibitor.?Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237.?Interestingly, Tripolin A affected the gradient distribution towards the chromosomes, but not the MT binding of HURP (Hepatoma Up-Regulated Protein), a MT-associated protein (MAP) and substrate of the Aurora A kinase.?Therefore Tripolin A reveals a new way of regulating mitotic MT stabilizers through Aurora A phosphorylation.?
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体外实验Tripolin A induces mitotic spindle defects and spindle pole abnormalities.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点Aurora Kinase
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受体Aurora A
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研究领域——
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适应症——
化学信息
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CAS Number1148118-92-6
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分子量253.25
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分子式C15H11NO3
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纯度>98% (HPLC)
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溶解度——
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SMILESOc3cc(/C=C1\c2ccccc2NC1=O)c(O)cc3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485.
