CPYPP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CPYPP 是 DOCK2-Rac1 相互作用的抑制剂。 CPYPP 与 DOCK2 DHR-2 结构域结合，并以剂量依赖性方式抑制 DOCK2DHR-2 对 Rac1 的鸟嘌呤核苷酸交换因子 (GEF) 活性 (IC50：22.8 μM)。

CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9CPYPP as a small-molecule inhibitor of DOCK2.?CPYPP bound to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.?When lymphocytes were treated with CPYPP, both chemokine receptor- and antigen receptor-mediated Rac activation were blocked, resulting in marked reduction of chemotactic response and T cell activation.?These results provide a rational of and a chemical scaffold for development of the DOCK2-targeting immunosuppressant.

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Others

Other Targets

DOCK2-Rac1|DOCK180|DOCK5|DOCK9

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310460-39-0

324.76

C18H13ClN2O2

>98% (HPLC)

DMSO : 23 mg/mL (70.82 mM; Need ultrasonic)

ClC1=CC=CC=C1C=CC=C1C(=O)NN(C1=O)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years