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Mitochonic acid 5
CAS No. 1354707-41-7
Mitochonic acid 5 ( MA-5 )
产品货号. M22041 CAS No. 1354707-41-7
线粒体酸 5 是植物激素吲哚-3-乙酸的衍生物。线粒体酸 5 结合线粒体并改善肾小管和心肌细胞损伤。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥629 | 有现货 |
|
| 10MG | ￥1017 | 有现货 |
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| 25MG | ￥2000 | 有现货 |
|
| 50MG | ￥3236 | 有现货 |
|
| 100MG | ￥4464 | 有现货 |
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| 200MG | ￥6174 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥692 | 有现货 |
|
生物学信息
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产品名称Mitochonic acid 5
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述线粒体酸 5 是植物激素吲哚-3-乙酸的衍生物。线粒体酸 5 结合线粒体并改善肾小管和心肌细胞损伤。
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产品描述Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis.
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体外实验——
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体内实验——
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同义词MA-5
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通路Others
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靶点Other Targets
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受体Mitochondrial Metabolism
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研究领域——
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适应症——
化学信息
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CAS Number1354707-41-7
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分子量329.3
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分子式C18H13F2NO3
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纯度>98% (HPLC)
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溶解度DMSO:95 mg/mL (288.49 mM)
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SMILESOC(=O)C(CC(=O)C1=C(F)C=C(F)C=C1)C1=CNC2=CC=CC=C12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.2. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.
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