Taltirelin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

他替瑞林是促甲状腺素释放激素受体 (TRH-R) 超级激动剂（IC50 为 910 nM，EC50 为 36 nM，可刺激胞质 Ca2+ 浓度（Ca2+ 释放）增加。

Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].Taltirelin (TAL), in mouse models of CRF.?To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors.?We used the treadmill fatigue test to assess fatigue-like behavior after treatment with TAL.?Additionally, we used wild-type and TRH receptor knockout mice to determine which TRH receptor was necessary for the actions of TAL.?Tumor-bearing mice displayed muscle wasting and all models caused fatigue-like behavior, with mice running a shorter distance in the treadmill fatigue test than controls.?TAL reversed fatigue-like behavior in all three models and the mouse TRH1 receptor was necessary for the effects of TAL.?These data suggest that TAL may be useful in alleviating fatigue in all cancer patients and provide further support for evaluating TAL as a potential therapy for CRF in humans.

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TA-0910

Others

Other Targets

Thyrotropin-releasing hormone receptor

Nervous system

Spinocerebellar Degeneration

103300-74-9

405.41

C17H23N7O5

>98% (HPLC)

DMSO:30 mg/mL (74 mM)

CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years