ML-109

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML-109 是促甲状腺激素受体 (TSHR) 的有效激动剂（EC50 为 40 nM）ML-109 是 TSHR 的完全激动剂，EC50 为 40 nM，对 FSHR 或 LHCGR 无活性。

ML-109 is a potent agonist of thyroid stimulating hormone receptor (TSHR) (EC50 of 40 nM)ML-109 is a full agonist at TSHR with an EC50 of 40 nM ,has no activity at FSHR or LHCGR.

ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h).

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Others

Other Targets

thyrotropin receptor (TSHR)

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1186649-91-1

523.58

C31H29N3O5

>98% (HPLC)

DMSO:83.33 mg/mL (159.15 mM; Need ultrasonic)

COc1ccc(cc1COc1ccc(NC(C)=O)cc1)C1Nc2cccc(O)c2C(=O)N1Cc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years