021-51111890
购物车（）
sales@molnova.cn
M8-B Hydrochloride
CAS No. 883976-12-3
M8-B Hydrochloride ( —— )
产品货号. M21971 CAS No. 883976-12-3
M8-B Hydrochronide 是一种选择性瞬时受体电位 melastatin-8 (TRPM8) 通道拮抗剂。M8 B，一种 TRPM8 拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥472 | 有现货 |
|
| 10MG | ￥661 | 有现货 |
|
| 25MG | ￥1386 | 有现货 |
|
| 50MG | ￥2213 | 有现货 |
|
| 100MG | ￥3051 | 有现货 |
|
| 200MG | ￥4257 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥542 | 有现货 |
|
生物学信息
-
产品名称M8-B Hydrochloride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述M8-B Hydrochronide 是一种选择性瞬时受体电位 melastatin-8 (TRPM8) 通道拮抗剂。M8 B，一种 TRPM8 拮抗剂。
-
产品描述M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.
-
体外实验——
-
体内实验Animal Model:Trpm8+/+ rats and mice Dosage:6 mg/kg Administration:I.v. or i.p.Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.
-
同义词——
-
通路Membrane Transporter/Ion Channel
-
靶点TRP/TRPV Channel
-
受体TRPM8
-
研究领域——
-
适应症——
化学信息
-
CAS Number883976-12-3
-
分子量432.96
-
分子式C22H25ClN2O3S?
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 250 mg/mL (577.42 mM)
-
SMILESCl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Zandi N , Zaniani N R , Moghimi A , et al. Protective effects of M8?B, a TRPM8 antagonist, on febrile? and pentylenetetrazol?induced seizures[J]. Acta neurobiologiae experimentalis, 2019, 79(1):86-91.
2. Almeida M C , Hew-Butler T , Soriano R N , et al. Pharmacological Blockade of the Cold Receptor TRPM8 Attenuates Autonomic and Behavioral Cold Defenses and Decreases Deep Body Temperature[J]. Journal of Neuroscience, 2012, 32(6):2086-2099.
产品手册
关联产品
-
GsMTx4
GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor.
-
CIM0216
CIM0216 是一种合成的 TRPM3 激活剂，其效力和表观亲和力大大超过经典的 TRPM3 激动剂。
-
Pinokalant
Pinokalant 是一种广谱阳离子通道抑制剂。Pinokalant 显着减少皮质梗死体积。Pinokalant 改善缺血半影区的代谢和电生理状态。Pinokalant 可减少大鼠大脑中动脉闭塞后急性期磁共振图像上的病变大小。Pinokalant 具有研究脑卒中的潜力。
