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Dantrolene
CAS No. 7261-97-4
Dantrolene ( —— )
产品货号. M21969 CAS No. 7261-97-4
Dantrolene 是一种突触后肌肉松弛剂，通过拮抗兰尼碱受体来抑制肌浆网储存的 Ca2+ 离子释放。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥511 | 有现货 |
|
| 10MG | ￥724 | 有现货 |
|
| 25MG | ￥995 | 有现货 |
|
| 50MG | ￥1442 | 有现货 |
|
| 100MG | ￥1773 | 有现货 |
|
| 200MG | ￥2538 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥351 | 有现货 |
|
生物学信息
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产品名称Dantrolene
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Dantrolene 是一种突触后肌肉松弛剂，通过拮抗兰尼碱受体来抑制肌浆网储存的 Ca2+ 离子释放。
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产品描述Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
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体外实验RT-PCR Cell Line:Porcine aortic valvular interstitial cells (paVICs) Concentration:60 μM Incubation Time:At 1 and 3 days Result:Significantly inhibited ACTA2 expression and upregulated RUNX2 expression.
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体内实验Animal Model:YAC128 transgenic mice (FVBN/NJ background strain) and WT mice Dosage:5 mg/kg Administration:Fed orally twice per week from 2 to 11.5 months of age Result:Resulted in significantly improved performance in the beam-walking and gait-walking assays. Significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates.
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同义词——
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通路Others
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靶点Other Targets
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受体Ryanodine receptor
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研究领域Cerebrovascular system
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适应症Subarachnoid HemorrhageCerebral Vasospasm
化学信息
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CAS Number7261-97-4
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分子量314.25
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分子式C14H10N4O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 20 mg/mL (63.64 mM)
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SMILES[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Diszhazi G , Magyar Z E , Motyan J A , et al. Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor[J]. Molecular Pharmacology, 2019, 96(3):mol.119.116475.
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