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BI-409306
CAS No. 1189767-28-9
BI-409306 ( —— )
产品货号. M21934 CAS No. 1189767-28-9
BI-409306 是一种有效的选择性 PDE9A 抑制剂（IC50 为 52 nM），可用于记忆研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥426 | 有现货 |
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| 5MG | ￥733 | 有现货 |
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| 10MG | ￥1150 | 有现货 |
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| 25MG | ￥1841 | 有现货 |
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| 50MG | ￥3404 | 有现货 |
|
| 100MG | ￥4752 | 有现货 |
|
| 200MG | ￥6705 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥805 | 有现货 |
|
生物学信息
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产品名称BI-409306
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述BI-409306 是一种有效的选择性 PDE9A 抑制剂（IC50 为 52 nM），可用于记忆研究。
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产品描述BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.(In Vitro):Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices.
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体外实验Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices.
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体内实验——
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同义词——
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通路Angiogenesis
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靶点PDE
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受体PDE9A
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研究领域Nervous system
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适应症Alzheimer Disease
化学信息
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CAS Number1189767-28-9
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分子量311.34
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分子式C16H17N5O2
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纯度>98% (HPLC)
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溶解度DMSO:22 mg/ml(50.06 mM)
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SMILESO=c1[nH]c(Cc2ccccn2)nc2n(ncc12)C1CCOCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cornelia Dorner-Ciossek, R. Giovannini, Holger Rosenbrock. BI 409306, A NOVEL PHOSPHODIESTERASE 9A INHIBITOR, PART I: POTENCY, SELECTIVITY AND IN-VITRO FUNCTIONAL CHARACTERIZATION ON SYNAPTIC PLASTICITY[C]// International Congress on Schizophrenia Research. 2015.
