Stepharine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Stepharine 是天然的生物碱，可直接靶向 TLR4 (TLR4 抑制剂)，结合 TLR4/MD2 复合体。Stepharine 具有抗衰老、抗病毒和抗高血压等活性。

Alkaloids.

Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells.Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation.Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro.

Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex. Animal Model:Middle cerebral artery occlusion (MCAO) rat model.Dosage:500 μg/kg (20 μL)Administration:Intranasally injected into rats 1h after MCAO.Result:Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.

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Others

Other Targets

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2810-21-1

297.3

C18H19NO3

>98% (HPLC)

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

COC1=C(C2=C3C(CC24C=CC(=O)C=C4)NCCC3=C1)OC

10,11-dimethoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one

(-20℃)

With Ice Pack

≥ 2 years