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Amodiaquine
CAS No. 86-42-0
Amodiaquine ( —— )
产品货号. M21611 CAS No. 86-42-0
阿莫地喹是一种合成氨基喹啉，用于治疗疟疾。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥568 | 有现货 |
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| 5MG | ￥947 | 有现货 |
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| 10MG | ￥1416 | 有现货 |
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| 25MG | ￥2483 | 有现货 |
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| 50MG | ￥3618 | 有现货 |
|
| 100MG | ￥5013 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥946 | 有现货 |
|
生物学信息
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产品名称Amodiaquine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述阿莫地喹是一种合成氨基喹啉，用于治疗疟疾。
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产品描述Amodiaquine is a synthetic aminoquinoline used to treat malaria.(In Vitro):Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.(In Vivo):Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
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体外实验Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells. RT-PCR Cell Line:Primary microglia Concentration:10 μM, 15 μM, 20 μM Incubation Time:4 hours Result:Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
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体内实验Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice. Animal Model:Male ICR mice (8-10?weeks of age) induced ntracerebral hemorrhage (ICH) Dosage:40 mg/kg Administration: Intraperitoneal injection; daily; for 3 daysResult:Diminished perihematomal activation of microglia/macrophages and astrocytes.
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同义词——
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通路Others
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靶点Other Targets
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受体Nurr1
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研究领域Infection
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适应症Malaria
化学信息
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CAS Number86-42-0
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分子量355.86
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分子式C20H22ClN3O
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纯度>98% (HPLC)
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溶解度DMSO:71 mg/mL (199.52 mM)
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SMILESCCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Keita Kinoshita Koseiet al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage.[J]. Journal of Neuroimmunology 2019.
产品手册
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